PROSPECTS OF HISTOMORPHOLOGICAL AND GENETIC DIAGNOSIS OF AUTOPSY-NEGATIVE SUDDEN CARDIAC DEATH

The article presents the prospects of histological and genetic diagnosis in cases of sudden cardiac death, where initial autopsy results do not reveal any obvious pathological changes. In recent years, there has been an increase in cases of autopsy-negative sudden cardiac death, creating a foundation for the development of methods for more accurate diagnosis of the causes of fatal outcomes and potential prevention of similar cases in the future. The article discusses modern methods of histological examination of heart tissues, as well as approaches to molecular genetic testing that may be useful in identifying subclinical conditions leading to sudden cardiac death. Molecular genetic methods for studying sudden cardiac death are still underexplored; therefore, the intersection of medical genetics, pathological anatomy, and forensic expertise is a very important and promising area in domestic medicine. Currently, there are few large-scale studies on the molecular genetic causes of sudden cardiac death in Russia, making the direction of diagnosing such fatal outcomes at the intersection of medical genetics, pathological anatomy, and forensic expertise particularly significant and promising in domestic medicine. This brief overview summarizes the results of histological and genetic diagnostics in cases of sudden cardiac death.