Russian Journal of Forensic MedicineRussian Journal of Forensic MedicineСудебная медицина2411-87292409-4161Eco-Vector30810.19048/2411-8729-2020-6-2-8-30Professional reviewsПрофессиональные обзоры专业评论PATHOLOGICAL ANATOMY OF INFECTION CAUSED BY SARS-COV-2ПАТОЛОГИЧЕСКАЯ АНАТОМИЯ ИНФЕКЦИИ, ВЫЗВАННОЙ SARS-COV-2https://orcid.org/0000-0002-1107-3753KoganE. A.КоганЕ. А.
Russian Federation

Dr. Sci. (Med.), Prof., Corresponding Member of the Russian Academy of Natural Sciences (RANS), Head of the A. I. Strukov Department of Pathological Anatomy,

Moscow

д.м.н., проф., член-корр. РАЕН, зав. кафедрой патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0001-5904-0021BerezovskyYu. S.БерезовскийЮ. С.
Russian Federation

Head of the Pathology Department,

Moscow

зав. отделением патологической анатомии,

Москва

report-q@yandex.ruhttps://orcid.org/0000-0002-5851-2768ProtsenkoD. D.ПроценкоД. Д.
Russian Federation

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

к.м.н., доц. кафедры патологической анатомии им. А. И. Струкова,

Москва

chief@medprint.ruhttps://orcid.org/0000-0001-9910-1570BagdasaryanT. R.БагдасарянТ. Р.
Russian Federation

Cand. Sci. (Med.), Chief Physician,

Moscow

к.м.н., главный врач,

Москва

cniit@ctri.ruhttps://orcid.org/0000-0002-2337-4692GretsovE. M.ГрецовЕ. М.
Russian Federation

Pathologist,

Moscow

врач-патологоанатом,

Москва

gem2505@yandex.ruhttps://orcid.org/0000-0001-9717-5496DemuraS. A.ДемураС. А.
Russian Federation

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

к.м.н., доц. кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0001-8447-2600DemyashkinG. A.ДемяшкинГ. А.
Russian Federation

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

к.м.н., доц. кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0001-6247-9481KalininD. V.КалининД. В.
Russian Federation

Cand. Sci. (Med.), Head of the Pathology Department,

Moscow

к.м.н., зав. патологоанатомическим отделением,

Москва

dmitry.v.kalinin@gmail.comhttps://orcid.org/0000-0002-6690-3347KuklevaA. D.КуклеваА. Д.
Russian Federation

Postgraduate Student of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

аспирант кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0002-3208-534XKurilinaE. V.КурилинаЭ. В.
Russian Federation

Head of the Pathology Department,

Moscow

зав. отделением патологической анатомии,

Москва

ellakurilina@yandex.ruhttps://orcid.org/0000-0001-6376-9392NekrasovaT. P.НекрасоваТ. П.
Russian Federation

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

к.м.н., доц. кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0001-5380-7113ParamonovaN. B.ПарамоноваН. Б.
Russian Federation

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

к.м.н., доц. кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0002-4242-5723PonomarevA. B.ПономаревА. Б.
Russian Federation

Cand. Sci. (Med.), Assoc. Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

к.м.н., доц. кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0002-4669-260XRadenska-LopovokS. G.Раденска-ЛоповокС. Г.
Russian Federation

Dr. Sci. (Med.), Prof. of the A. I. Strukov Department of Pathological Anatomy,

Moscow

д.м.н., проф. кафедры патологической анатомии им. А. И. Струкова,

Москва

https://orcid.org/0000-0002-1782-7763SemyonovaL. A.СеменоваЛ. А.
Russian Federation

Cand. Sci. (Med.), Senior Researcher of the Department of Pathomorphology, Cell Biology and Biochemistry,

Moscow

к.м.н., старший научный сотрудник отдела патоморфологии, клеточной биологии и биохимии,

Москва

lu.kk@yandex.ruhttps://orcid.org/0000-0001-5635-6100TertychnyA. S.ТертычныйА. С.
Russian Federation

Dr. Sci. (Med.), Prof. of the A. I. Strukov Department of Pathological Anatomy, 

Moscow

д.м.н., проф. кафедры патологической анатомии им. А. И. Струкова,

Москва

I. M. Sechenov First Moscow State Medical UniversityФГАОУ ВО «Первый Московский государственный медицинский университет им. И. М. Сеченова» Министерства здравоохранения Российской ФедерацииCentral Tuberculosis Research InstituteФГБНУ «Центральный научно-исследовательский институт туберкулеза»A. V. Vishnevsky National Medical Research CenterФГБУ «Национальный медицинский исследовательский центр хирургии им. А. В. Вишневского» Министерства здравоохранения Российской ФедерацииNational Medical Research Center of CardiologyФГБУ «Национальный медицинский исследовательский центр кардиологии» Министерства здравоохранения Российской Федерации02072020628300107202001072020Copyright ©; 2020, Kogan E.A., Berezovsky Y.S., Protsenko D.D., Bagdasaryan T.R., Gretsov E.M., Demura S.A., Demyashkin G.A., Kalinin D.V., Kukleva A.D., Kurilina E.V., Nekrasova T.P., Paramonova N.B., Ponomarev A.B., Radenska-Lopovok S.G., Semyonova L.A., Tertychny A.S.Copyright ©; 2020, Коган Е.А., Березовский Ю.С., Проценко Д.Д., Багдасарян Т.Р., Грецов Е.М., Демура С.А., Демяшкин Г.А., Калинин Д.В., Куклева А.Д., Курилина Э.В., Некрасова Т.П., Парамонова Н.Б., Пономарев А.Б., Раденска-Лоповок С.Г., Семенова Л.А., Тертычный А.С.2020Kogan E.A., Berezovsky Y.S., Protsenko D.D., Bagdasaryan T.R., Gretsov E.M., Demura S.A., Demyashkin G.A., Kalinin D.V., Kukleva A.D., Kurilina E.V., Nekrasova T.P., Paramonova N.B., Ponomarev A.B., Radenska-Lopovok S.G., Semyonova L.A., Tertychny A.S.Коган Е.А., Березовский Ю.С., Проценко Д.Д., Багдасарян Т.Р., Грецов Е.М., Демура С.А., Демяшкин Г.А., Калинин Д.В., Куклева А.Д., Курилина Э.В., Некрасова Т.П., Парамонова Н.Б., Пономарев А.Б., Раденска-Лоповок С.Г., Семенова Л.А., Тертычный А.С.https://creativecommons.org/licenses/by-nc/4.0https://for-medex.ru/jour/article/view/308

Autopsy data from 80 patients who died of the COVID-19 infection were analysed. Using macro- and microscopic studies, specific features of pathological processes in various organs were identified. The obtained experimental data, along with information from literature sources, allowed conclusions to be drawn about the mechanisms of damaging internal organs and body systems, as well as assumptions to be made about individual links in the pathogenesis of COVID-19. The thanatogenesis of the disease and the main causes of death are discussed, including acute cardiopulmonary failure, acute renal failure, pulmonary thromboembolism, shock involving multiple organ failure and sepsis. The critical importance of autopsy is emphasized, which provides valuable information on the morphological substrate for this infection closely associated with possible clinical manifestations.

Материалом для исследования послужили данные 80 аутопсий пациентов, страдавших инфекцией COVID-19. При помощи макро- и микроскопического исследований продемонстрированы особенности патологических процессов в различных органах. Полученные данные в сочетании со сведениями из литературы позволяют сделать выводы о закономерностях поражения внутренних органов и систем организма, а также высказать предположения об отдельных звеньях патогенеза COVID-19. Обсуждается танатогенез при данном заболевании и основные причины смерти, к которым относятся: острая сердечно-легочная недостаточность, острая почечная недостаточность, тромбоэмболия легочной артерии, шок с полиорганной недостаточностью и сепсис. Подчеркивается чрезвычайная важность проведения аутопсий, которые несут неоценимую информацию о морфологическом субстрате данной инфекции, тесно связанном с возможными клиническими проявлениями.

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